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pentobarbital will lessen the extent or effect of buprenorphine, extended-acting injection by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Closely. Patients who transfer to buprenorphine extended-acting injection from transmucosal buprenorphine coadministered with CYP3A4 inducers ought to be monitored to be sure bupre